The inter-reader agreement, as calculated using Cohen’s Kappa and Fleiss' Kappa coefficients, was slightly higher for the high-frequency probe (HFP) compared to the values obtained for the classic linear probe (CLP). This finding suggests that the use of high-frequency ultrasound enhances consistency among radiologists in interpreting retroareolar lesions, a region that is particularly challenging due to its complex anatomical structure and the presence of imaging artifacts.

The improved agreement indicates that HFP provides clearer, more detailed visualization of anatomical features, allowing for more accurate lesion characterization. This, in turn, increases diagnostic confidence and reduces variability among readers, ultimately contributing to more reliable and reproducible clinical assessments. The ability to better delineate structures and differentiate between benign and potentially malignant findings is crucial in reducing diagnostic uncertainty and improving patient management.

Given these advantages, integrating high-frequency transducers into routine clinical practice can serve as a valuable tool for enhancing radiologists’ confidence in evaluating retroareolar lesions. By offering superior image resolution and reducing interpretative discrepancies, HFP may play a pivotal role in optimizing breast ultrasound protocols and advancing the accuracy of retroareolar lesion assessment.