This study demonstrated the significant potential of hybrid PET/MRI imaging, particularly for detecting BCR in PCa patients after radical prostatectomy. The combination of PET and MRI in a single session offers notable advantages, including enhanced diagnostic accuracy and reduced imaging times, which improve patient compliance and the overall diagnostic workflow. Hybrid PET/MRI allows for comprehensive evaluation by merging the high sensitivity of PET imaging, which excels in identifying even the smallest pathological lesions, with the superior anatomical resolution provided by MRI. This combination is particularly useful in complex clinical cases where other imaging modalities may fail to provide conclusive results. One of the key findings of this study was the ability of hybrid imaging to achieve a 90% concordance rate between PET and MRI diagnoses, highlighting its reliability. Additionally, the efficiency of the system was demonstrated by reducing the waiting time and improving patient throughput. With a shorter acquisition time (35-40 minutes per session), this protocol proved to be both time-efficient and clinically valuable. However, several challenges remain. The study revealed a 10% discrepancy between PET and MRI results, particularly in detecting lesions in certain regions, such as the chest or lymph nodes. These findings emphasize the necessity of further refinement of hybrid protocols to ensure greater diagnostic accuracy. Furthermore, although promising, PET/MRI technology remains costly compared with PET/CT systems. The initial investment and maintenance may limit the widespread adoption of PET/MRI in clinical practice.
The implementation of sequences, such as ZTE or high-resolution Fiesta, could greatly improve chest and mediastinum imaging, thereby addressing a major challenge in this area. Moreover, ultra-advanced sequences, such as IVIM diffusion or Luminal Water Imaging combined with hybrid PET/MRI, could lead to a reduced dependence on contrast agents, limiting their use to only the most necessary cases. The future of hybrid imaging has just begun. The implementation of research protocols and commercialization of new equipment will open the way for the widespread adoption of PET/MRI across various clinical fields.

