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Congress: ECR25
Poster Number: C-17667
Type: Poster: EPOS Radiologist (educational)
DOI: 10.26044/ecr2025/C-17667
Authorblock: S. M. Pizzileo, F. Pizzolorusso, G. Iacobellis, S. De Lorenzis, G. M. A. D'Arma, G. Fascia, M. Masciavè, M. Montatore, G. Guglielmi; Foggia/IT
Disclosures:
Sara Maria Pizzileo: Nothing to disclose
Francesco Pizzolorusso: Nothing to disclose
Giulia Iacobellis: Nothing to disclose
Stefano De Lorenzis: Nothing to disclose
Giuseppe Maria Andrea D'Arma: Nothing to disclose
Giacomo Fascia: Nothing to disclose
Maurizio Masciavè: Nothing to disclose
Manuela Montatore: Nothing to disclose
Giuseppe Guglielmi: Nothing to disclose
Keywords: Abdomen, Bones, Haematologic, CT, Surgery, Education and training, Haematologic diseases
Learning objectives To describe the main radiological features of multiorgan involvement in beta-thalassemia major.
Read more Background The term "thalassemia" refers to a group of hereditary disorders characterized by a deficiency or impaired synthesis of certain globin chains that constitute hemoglobin. The most commonly affected chains are the alpha and beta chains, with beta thalassemia being the most prevalent form.The phenotypic expression of beta thalassemia is highly variable, ranging from almost asymptomatic conditions, such as thalassemia minor or thalassemia trait, to intermediate forms of the disease (thalassemia intermedia), and to the most severe form, thalassemia major.Beta-thalassemia major, also known as Cooley's...
Read more Findings and procedure details Radiological imaging is vital for assessing and following up on patients with beta thalassemia, enabling evaluation of both skeletal and extraosseous tissue involvement.In some cases, clinical manifestations arise from severe chronic anemia that induces increased erythropoietin production. Erythropoietin stimulates the conversion of yellow marrow into hematopoietic red marrow in the bone. Medullary hyperplasia often leads to widening of medullary spaces, causing conglomeration and loss of normal trabecular structure. The expanding mass of red blood cell precursors can erode the bone...
Read more Conclusion Early identification of key radiological features is crucial for appropriate patient follow-up and therapeutic adjustments essential for improving patient survival.
Read more References Galanello, R., Origa, R. Beta-thalassemia. Orphanet J Rare Dis 5, 11 (2010). https://doi.org/10.1186/1750-1172-5-11 Vinay Kumar, Abul K. Abbas, Jon C. Aster. Robbins Basic Pathology. - 9. Ed. (2013) ISBN: 9781437717815 - Google Books Tyler PA, Madani G, Chaudhuri R, Wilson LF, Dick EA. The radiological appearances of thalassaemia. Clin Radiol. 2006 Jan;61(1):40-52. doi: 10.1016/j.crad.2005.07.006. PMID: 16356815. Hajimoradi M, Haseli S, Abadi A, Chalian M. Musculoskeletal imaging manifestations of beta-thalassemia. Skeletal Radiol. 2021 Sep;50(9):1749-1762. doi: 10.1007/s00256-021-03732-9. Epub 2021 Feb 9. PMID: 33559685. Prakash UB. Lungs in...
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