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Congress: ECR25
Poster Number: C-12148
Type: Poster: EPOS Radiologist (scientific)
DOI: 10.26044/ecr2025/C-12148
Authorblock: D. Juskanic1, S. Holly1, G. Zuzana1, S. Kalafútová2, Z. Berecova3, A. Obert1, L. Patrovic1, M. Chmelik2; 1Nitra/SK, 2Presov/SK, 3Bratislava/SK
Disclosures:
Dominik Juskanic: Speaker: Boehringer Ingelheim, Sanofi, Roche
Samuel Holly: Nothing to disclose
Gaziova Zuzana: Nothing to disclose
Soňa Kalafútová: Nothing to disclose
Zuzana Berecova: Nothing to disclose
Adam Obert: Nothing to disclose
Lukas Patrovic: Nothing to disclose
Marek Chmelik: Nothing to disclose
Keywords: Lung, Thorax, CT-High Resolution, CT-Quantitative, Computer Applications-3D, Chronic obstructive airways disease, Epidemiology
Purpose High-Resolution Computed Tomography (HRCT) has long been a fundamental tool in the diagnostic imaging of interstitial lung diseases (ILDs). Traditionally, its interpretation relies on qualitative assessments of morphological and architectural changes within the lung parenchyma, often identifying specific disease patterns. While this method is crucial for accurate diagnosis, it lacks the necessary interobserver reproducibility for quantifying disease extent and progression.In recent years, advancements in quantitative analysis techniques for imaging data have emerged. Its integration into clinical decision-making is hindered by...
Read more Methods and materials To establish thresholds for healthy lung volumes on CT, we analyzed a subcohort from an ongoing ultra-low-dose chest photon-counting CT study focused on incidental lung nodules during coronary CT angiography (n=659). We employed rigorous criteria to define "healthy subjects," which included a BMI of less than 35, an Agatston Calcium Score of less than 100, and no history of smoking, asthma, or dyspnea. After manual revision of the remaining 131 subjects, we excluded individuals with signs of prior chest surgery (either...
Read more Results Age- and sex-specific reference ranges for CT-derived TLV in healthy Caucasian adults were calculated with following equations: For the predicted TLCct median and variability respectively in males: exp(-17.2472+0.0853 * log[age] + 3.5829 * log[height]); exp(9.8+0.471*log[age] + -2.539*log[height]). For females: exp(-12.2016+0.05813 * log[age] + 2.6292 * log[height]); exp(-2.7115+-0.5220*log[age] + 0.6064*log[height]).Wormplots for both males and females show in the y-axis deviations from the theoretical normal distribution. Our dataset shows a slight curvature, which suggests minor deviations from normality with points remaining within the confidence...
Read more Conclusion Establishing reliable reference values for CT-derived total lung capacity (TLCct) is vital for advancing qHRCT as a clinically relevant tool. We present initial data from a healthy cohort, in order to aid the interpretation of qHRCT results in the future.
Read more References Eur Respir J 2012; 40: 1324–1343 DOI: 10.1183/09031936.00080312Eur Respir J  2023 62: PA3667; DOI: 10.1183/13993003.congress-2023.PA3667PLoS ONE 18(6): e0287383. https://doi.org/10.1371/journal.pone.0287383Eur Respir J 2024; 63:2300370 DOI: 10.1183/13993003.00370-2023Eur Respir J 2021; 57: 2000289 [https://doi.org/10.1183/13993003.00289-2020].
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