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Congress: ECR26
Poster Number: C-20201
Type: Poster: EPOS Radiologist (scientific)
Authorblock: D. M. Humphreys1, D. Amiras2, H. Lanz2, C. Gupte2, J. Mcginley2, K. Chappell2, M. Ristic2; 1Bedford/UK, 2London/UK
Disclosures:
Daniel Michael Humphreys: Nothing to disclose
Dimitri Amiras: Nothing to disclose
Harry Lanz: Nothing to disclose
Chinmay Gupte: Nothing to disclose
John Mcginley: Nothing to disclose
Karyn Chappell: Nothing to disclose
Mihailo Ristic: Nothing to disclose
Keywords: Musculoskeletal soft tissue, Experimental, Diagnostic procedure, Trauma
Purpose Non-invasive, accurate assessment of anterior cruciate ligament (ACL) injury where disruption to baseline collagen structure is subtle and gross morphological changes are absent remains challenging. Although magnetic resonance imaging (MRI) is routinely used for ACL evaluation, conventional sequences lack sensitivity to capture collagen fibre anisotropy and typically rely on negative contrast, such as adjacent fluid, rather than direct visualisation of the disrupted collagen structure[1-3]. Magic angle directional imaging (MADI) is a novel MRI technique that acquires images at multiple orientations to...
Read more Methods and materials This proof-of-concept exploratory study used retrospective MADI data from samples previously acquired by the MADI research group from Imperial College London (Figure 1) [4]. Four human ACL samples were analysed, representing a range of tissue conditions: healthy, partially torn, completely torn and reconstructed ligaments. All data was anonymised prior to analysis. Ethical approval for secondary analysis was confirmed under the framework of the original study by Imperial College London Ethics Committee.Segmentation and Vector Field Generation:Regions of interest corresponding to the...
Read more Results Validation of FC on in silico vector fields performed as expected under controlled conditions. Perfectly aligned vectors produced minimal FC values while increasing levels of disruption were reflected by increasingly higher FC values. FC was also able to capture isolated angular disruptions and identify transition points where FC values changed abruptly. This confirmed the metric’s sensitivity to local deviations from uniform collagen alignment.Following application of FC to MADI-derived vector fields from the human ACL samples, distinct differences between healthy and...
Read more Conclusion This proof-of-concept exploratory study demonstrates the feasibility of deriving a quantitative, three-dimensional metric of collagen organisation from MADI-derived vector fields to enhance ACL visualisation beyond conventional tractography alone. The FC metric was sensitive to local deviations in mesoscopic scale collagen alignment under controlled conditions. Additionally, FC revealed biologically plausible patterns in human ACLs. In particular, a centrally located band of uniform collagen organisation was observed in healthy tissue, consistent with literature describing native ACL mid-substance structure[10,16,17]. The absence of this...
Read more Personal information Imperial College London
Read more References [1] - Li K, Du J, Huang LX, Ni L, Liu T, Yang HL. The diagnostic accuracy of magnetic resonance imaging for anterior cruciate ligament injury in comparison to arthroscopy: a meta-analysis. Sci Rep. 2017 Aug 8;7(1):7583.[2] - Strocchi R, de Pasquale V, Gubellini P, Facchini A, Marcacci M, Buda R, et al. The human anterior cruciate ligament: histological and ultrastructural observations. J Anat. 1992 Jun;180(Pt 3):515–9.[3] - Hasegawa A, Nakahara H, Kinoshita M, Asahara H, Koziol J, Lotz MK....
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