The high success rate of the procedure of 86.3% correlates with larger studies done earlier. The percentage of complications of 74.1% seems high, but let's take into account that the percentage of minor complications is 64% and major complications are 10.1%. These results speak in favor of the justification of performing the procedure.

As seen in our and many more studies smoking status and destruction of lung parenchima by emphysematous changes can severly increase the risk of pneumothorax. Before each procedure, it is necessary to plan the route of the needle to the lesion and anticipate all possible complications. In the context of lung biopsy complications, particularly pertinent to patients with emphysema and those who smoke, additional considerations come into play.Emphysema, characterized by damaged and fragile lung tissue, poses an increased risk of complications such as prolonged air leaks and respiratory distress post-biopsy. Moreover, smoking exacerbates these risks due to compromised lung function and impaired healing capacity.Despite these challenges, the diagnostic benefits of lung biopsy in guiding treatment decisions cannot be understated. Close collaboration between pulmonologists, radiologists, and respiratory therapists is essential to tailor procedural strategies that minimize risks while maximizing diagnostic yield. Emphasizing patient education on smoking cessation and respiratory health management further enhances post-biopsy recovery and long-term outcomes. Thus, while acknowledging the complexities involved, proactive management and patientcentered care remain integral in navigating the intricacies of lung biopsy in this vulnerable patient population.