Quantitative biomarker such as volume measurement is essential for various neurodegenerative disorder patients in diagnosis or prediction of disease progression (1). Introducing of high resolution MRI such as three dimensional T1 Magnetization Prepared Rapid Acquisition Gradient Echo (MPRAGE) made it possible to investigate not only anatomic morphology but also quantitative data combined with volume measure software. However, relatively long acquisition time requires patients to remain still for prolonged periods to ensure the adequate image quality which is one of the major obstacles to undergo the image study. In the last years, the compressed sensing (CS) acceleration technique has been combined with MPRAGE sequence and widely used in research field with great interest of high-contrast 3D images faster than standard MPRAGE. However, to use the CS-accelerated version of the MPRAGE in clinical practice and potentially replace the standard-MPRAGE, further investigation is required. We investigated volume data agreement and both qualitative and quantitative scores to evaluate its potential as an alternative to standard MPRAGE using commercially available automated volume measurement software (2).