To demonstrate in vivo redistribution of the blood flow towards HCC's lesions by utilizing two-dimensional perfusion angiography in b-TACE procedures.

Drug-eluting microsphere TACE (DEM-TACE) with the use of balloon microcatheter for temporary artery occlusion (b-TACE), has been proposed as a useful tool to improve drug deposition, leading to an improved treatment response over non-occluded procedures. The underlying mechanism permitting flow restoration beyond the temporary occluded segment, is the opening of intra-hepatic collaterals. This compensation mechanism has been also observed in in silico zero-dimensional and three-dimensional hepatic artery hemodynamics models by Aramburu et al. However, such numerical models are limited to the blood flow analysis only, and no numerical investigation of the distribution and accumulation of blood additives (e.g. embolic materials, contrast agents) has been reported to date