TS is a rare disease with an uncertain prognosis and no definitive treatment yet. Depending on the severity of the organ manifestations and the clinical course of TSC, patients require life-long monitoring, vigilant surveillance and coordination of care. While a benign condition, hamartomas can cause irreparable damage to a system’s regular function and lead to life-threatening complications (recurrent pneumothorax, chylothorax, renal failure, neurocognitive deficits etc.). Therefore, radiologic assessment with US, X-ray, CT and MRI has an important role in early detection of TSC features and, furthermore, in post-treatment evaluation.