Conclusion

Breast volume was lower while fibroglandular volume was higher for women with interval cancer compared to those with screen-detected cancer among participants of BreastScreen Norway, 2007-2020. Studies from comparable screening settings are needed to corroborate the results. Women with interval cancer have been shown to have a higher mammographic density and thus reduced mammographic sensitivity compared to women with screen-detected cancer (10). Our finding of consistently lower breast volume combined with high fibroglandular volume in women with interval versus screen-detected cancer might underline the need to consider low breast volume in combination with high mammographic breast density as a possible parameter for personalized approaches, including shorter screening intervals and/or additional screening tools (11).