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Congress: ECR25
Poster Number: C-16155
Type: Poster: EPOS Radiologist (scientific)
Authorblock: N. Moshina, J. Gjesvik, S. Sagstad, M. Larsen, Å. S. Holen, M. B. Bergan, S. Hofvind; Oslo/NO
Disclosures:
Nataliia Moshina: Nothing to disclose
Jonas Gjesvik: Nothing to disclose
Silje Sagstad: Nothing to disclose
Marthe Larsen: Nothing to disclose
Åsne Sørlien Holen: Nothing to disclose
Marie Burns Bergan: Nothing to disclose
Solveig Hofvind: Nothing to disclose
Keywords: Breast, Mammography, Screening, Cancer, Epidemiology
Purpose The association between breast volume and breast cancer risk has been shown to vary by age and ethnicity (1). Breast volume measurements were, however, based on subjective or two-dimensional assessments, while the amount of fibroglandular tissue was not considered (1, 2). In recent years, fully-automated systems for mammographic density assessment have been able to generate objective measurements of breast density and volume, providing the opportunity for studying the associations with breast cancer risk with higher precision than in previous studies (3)....
Read more Methods and materials Data were extracted from the Cancer Registry of Norway that administers BreastScreen Norway. The screening program started in 1996 and offers biennial mammography to women aged 50-69 years (7). Information about 4309 women screened and diagnosed with breast cancer, 3333 with screen-detected cancer and 976 with interval cancer, during the period January 1, 2007 – December 31, 2020, was included in the study. Breast volume (cm3) and fibroglandular volume (cm3) were measured by a fully-automated software for breast density assessment...
Read more Results Mean age at diagnosis and measurement of breast volume were 59.6 years (standard deviation, SD: 5.9) and 916.8 cm3 (SD: 464.7) for women with screen-detected cancer and 58.9 years (SD: 5.9) and 836.9 cm3 (SD: 446.5) for women with interval cancer (p<0.05 for both) (Figure 1). Mean breast volume increased while fibroglandular volume decreased by age at diagnosis (Figure 2AB). Further, mean breast volume was consistently lower, while mean fibroglandular volume was higher among women with interval cancer compared to...
Read more Conclusion ConclusionBreast volume was lower while fibroglandular volume was higher for women with interval cancer compared to those with screen-detected cancer among participants of BreastScreen Norway, 2007-2020. Studies from comparable screening settings are needed to corroborate the results. Women with interval cancer have been shown to have a higher mammographic density and thus reduced mammographic sensitivity compared to women with screen-detected cancer (10). Our finding of consistently lower breast volume combined with high fibroglandular volume in women with interval versus screen-detected...
Read more References Jansen LA, Backstein RM, Brown MH. Breast size and breast cancer: A systematic review. Journal of Plastic, Reconstructive & Aesthetic Surgery. 2014;67(12):1615-23. Eriksson N, Benton GM, Do CB, Kiefer AK, Mountain JL, Hinds DA, et al. Genetic variants associated with breast size also influence breast cancer risk. BMC Med Genet. 2012;13:53. Cheddad A, Czene K, Eriksson M, Li J, Easton D, Hall P, Humphreys K. Area and Volumetric Density Estimation in Processed Full-Field Digital Mammograms for Risk Assessment of Breast Cancer. PLOS...
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